This film tells the astounding, almost improbable, true story of one warm-hearted, stubborn man’s visionary quest to find a cure for cancer after the death of his mother. Today, Jim Allison is a name to be reckoned with throughout the scientific world — a 2018 Nobel Prize winner for discovering the immune system’s role in defeating cancer along with Tasuku Honjo — but for decades he waged a lonely struggle against the skepticism of the medical establishment and the resistance of Big Pharma. "Breakthrough" tells the story of how the path of Jim's life, punctuated by heartbreak, grief, perserverance and love, led to the Nobel Prize but it also shines a light on the electrifying nature of scientific discovery through it's portrayal of a modest, harmonica playing, blues loving, quiet genius of a man.